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Spectrum Pharmaceuticals Announces Third Quarter 2007 Financial Results and Pipeline Update

November 9, 2007 at 12:00 AM EST
Spectrum Pharmaceuticals Announces Third Quarter 2007 Financial Results and Pipeline Update

-- Approximately $66 Million in Cash and Equivalents as of September 30, 2007 -- Net Cash Use in Operations in the Third Quarter Was Approximately $5.4 Million

IRVINE, Calif.--(BUSINESS WIRE)--Nov. 9, 2007--Spectrum Pharmaceuticals, Inc. (Nasdaq:SPPI):
Conference Call:     12 p.m. Eastern/9 a.m. Pacific
Domestic:            866-831-6272
International:       617-213-8859
Passcode:            75143682
Webcast and replays: www.spectrumpharm.com

Spectrum Pharmaceuticals, Inc. (Nasdaq:SPPI) today reported financial results for the third quarter ended September 30, 2007.

The Company incurred a third quarter of 2007 net loss of approximately $7.4 million, or ($0.24) per basic and diluted share, compared to a net loss of approximately $7.4 million, or ($0.30) per share in the third quarter of 2006. Revenue in the third quarter of 2007 included $3.2 million in milestone payments from GPC Biotech. Research and development expenses were approximately $6.8 million in the third quarter 2007, compared to approximately $5.8 million in the third quarter of 2006, due to the expanded scope of the Company's clinical development activities. General and administrative expenses were approximately $2.4 million in the third quarter of 2007, compared to approximately $1.5 million in the third quarter 2006, primarily due to legal expenses. As of October 31, 2007, approximately 31.2 million shares were issued and outstanding.

During the nine-month period ended September 30, 2007, net cash used in operations was approximately $15.4 million, compared to approximately $13.3 million in the same nine-month period of 2006. As of September 30, 2007, the Company had cash, cash equivalents, and marketable securities on hand of approximately $65.8 million, compared to approximately $50.7 million as of December 31, 2006.

"We will continue to aggressively move our pipeline of late-stage drugs through the development process," said Rajesh C. Shrotriya, M.D., Chairman, President and Chief Executive Officer of Spectrum Pharmaceuticals. "While we are disappointed with the satraplatin setback, we do not rely on any one drug to achieve success."

Recent Highlights and Upcoming Milestones

-- ISO-Vorin(TM)
    -- Filed NDA Amendment in June 2007
    -- January 11, 2008 FDA Action Date
-- EOquin(R) (non-invasive bladder cancer)
    -- More than 170 patients enrolled to date
    -- Began enrolling patients in 2nd of two Phase 3 trials
    -- Adding 30+ sites in Canada
-- Ozarelix (benign prostate hypertrophy)
    -- Patients are being followed for safety and efficacy in Phase 2b
     trial; Results expected in 2Q08
    -- Currently planning and designing registrational trial to start
     early next year
-- Ortataxel (solid tumors)
    -- Planning Phase 2 study in non-small-cell lung cancer to start
     in 2Q08
    -- Optimum oral formulation under development
-- SPI-1620 (adjunct to chemotherapy)
    -- FDA cleared the IND application and protocol
    -- Phase 1 study ready to enroll patients following Institutional
     Review Board approvals
-- Satraplatin (hormone-refractory prostate cancer)
    -- Received almost $8 million in satraplatin-related revenue year-
     to-date

Conference Call

Spectrum Pharmaceuticals will host a conference call to discuss these financial results and pipeline update on:

   Friday, November 9, 2007 @ 12:00 p.m. Eastern/9:00 a.m. Pacific
----------------------------------------------------------------------
Domestic:                866-831-6272           passcode 75143682
International:           617-213-8859           passcode 75143682

Webcast and replays: www.spectrumpharm.com.

Audio replays will be available through November 16, 2007.
    Domestic:      888-286-8010, passcode 67949023
    International: 617-801-6888, passcode 67949023

About Spectrum Pharmaceuticals

Spectrum Pharmaceuticals acquires, develops and commercializes a diversified portfolio of oncology drug candidates that meet critical health challenges for which there are few other treatment options. The company's pipeline includes promising early and late-stage drug candidates with unique formulations and mechanisms of action that address the needs of seriously ill patients, such as at-home chemotherapy and new treatment regimens for refractory disease. For more information, please visit our website at www.spectrumpharm.com.

Forward-looking statement - This press release may contain forward-looking statements regarding future events and the future performance of Spectrum Pharmaceuticals that involve risks and uncertainties that could cause actual results to differ materially. These statements include but are not limited to statements that relate to our business and its future, Spectrum's ability to identify, acquire, develop and commercialize its portfolio of drug candidates, the Company's promising pipeline, that we will continue to aggressively move our pipeline of late-stage drugs through the development process, that we will add 30+ sites in Canada for the EOquin trial, that we expect results in 2Q08 from the ozarelix Phase 2b trial, that the ozarelix registrational trial will start early next year, that we are planning the Phase 2 study in non-small-cell lung cancer for ortataxel to start in 2Q08, that the Phase 1 study for SPI-1620 will begin enrolling patients following Institutional Review Board approvals, and any statements that relate to the intent, belief, plans or expectations of Spectrum or its management, or that are not a statement of historical fact. Risks that could cause actual results to differ include the possibility that our existing and new drug candidates may not prove safe or effective, the possibility that our existing and new drug candidates may not receive approval from the FDA, and other regulatory agencies in a timely manner or at all, the possibility that our existing and new drug candidates, if approved, may not be more effective, safer or more cost efficient than competing drugs, the possibility that our efforts to acquire or in-license and develop additional drug candidates may fail, our lack of revenues, our limited marketing experience, our dependence on third parties for clinical trials, manufacturing, distribution and quality control and other risks that are described in further detail in the Company's reports filed with the Securities and Exchange Commission. We do not plan to update any such forward-looking statements and expressly disclaim any duty to update the information contained in this press release except as required by law.

           SPECTRUM PHARMACEUTICALS, INC. AND SUBSIDIARIES
           (In thousands, except Share and per share data)

  Summary Condensed Consolidated Statement of Operations (Unaudited)

                         Quarter Ended           Nine Months Ended
                         September 30,             September 30,
                   ------------------------- -------------------------
                       2007         2006         2007         2006
                   ------------ ------------ ------------ ------------

Revenues           $     3,250  $        92  $     7,625  $        92
                   ========================= =========================
Operating
 expenses:
Cost of product
 sold                        -           97            -           97
Research and
 development             6,789        5,803       18,973       13,554
General and
 administrative          2,382        1,516        7,846        4,379
Stock-based
 charges                 2,388          738        4,617        6,306
                   ------------------------- -------------------------
  Total operating
   expenses             11,559        8,154       31,436       24,336
                   ------------------------- -------------------------

Loss from
 operations             (8,309)      (8,062)     (23,811)     (24,244)
Other income, net          927          660        2,259        1,949
                   ------------------------- -------------------------
Net loss before
 minority interest
 in consolidated
 subsidiary             (7,382)      (7,402)     (21,552)     (22,295)
Minority interest
 in net loss of
 consolidated
 subsidiary                  -            -           20            2
                   ------------------------- -------------------------
Net loss           $    (7,382) $    (7,402) $   (21,532) $   (22,293)
                   ========================= =========================
Basic and diluted
 net loss per
 share             $     (0.24) $     (0.30) $     (0.76) $     (0.93)
                   ========================= =========================
Basic and diluted
 weighted average
 common shares
 outstanding        31,034,241   24,485,369   28,276,992   23,934,749
                   ========================= =========================

Supplemental
 Information
Stock-based
 charges -
 Components:
  Research and
   development     $     1,743  $       447  $     3,052  $     5,233
  General and
   administrative          645          291        1,565        1,073
                   ------------------------- -------------------------
    Total stock
     based charges $     2,388  $       738  $     4,617  $     6,306
                   ========================= =========================


      Summary Condensed Consolidated Balance Sheets (Unaudited)

                                           September 30, December 31,
                                               2007          2006
                                           ------------- -------------

Cash, cash equivalents and marketable
 securities                                $      65,759 $      50,697
Accounts Receivable, net                           1,344         1,150
Other current assets                                 548           440
                                           ------------- -------------
Total current assets                              67,651        52,287
Property and equipment, net and other
 assets                                              948           830
                                           ------------- -------------
Total assets                               $      68,599 $      53,117
                                           ============= =============

Total liabilities                          $       9,383 $       7,268
Minority Interest                                      -            20
Stockholders' equity                              59,216        45,829
                                           ------------- -------------
Total liabilities and stockholders' equity $      68,599 $      53,117
                                           ============= =============
CONTACT: Spectrum Pharmaceuticals, Inc.
Russell Skibsted, SVP & Chief Business Officer
Paul Arndt, Manager, Investor Relations
949-788-6700
or
Media Contact:
Porter Novelli Life Sciences
Susan Neath, 619-849-6007

SOURCE: Spectrum Pharmaceuticals, Inc.