March 25, 2020

Joseph Turgeon
President and Chief Executive Officer
Spectrum Pharmaceuticals, Inc.
11500 South Eastern Avenue, Suite 240
Henderson, NV 89052

       Re: Spectrum Pharmaceuticals, Inc.
           Registration Statement on Form S-3
           Filed March 20, 2020
           File No. 333-237319

Dear Mr. Turgeon:

       This is to advise you that we have not reviewed and will not review your

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact William Mastrianna, Attorney-Adviser, at (202) 551-3778
with any


                                                            Division of
Corporation Finance
                                                            Office of Life
cc:    Teri O'Brien