March 25, 2020 Joseph Turgeon President and Chief Executive Officer Spectrum Pharmaceuticals, Inc. 11500 South Eastern Avenue, Suite 240 Henderson, NV 89052 Re: Spectrum Pharmaceuticals, Inc. Registration Statement on Form S-3 Filed March 20, 2020 File No. 333-237319 Dear Mr. Turgeon: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact William Mastrianna, Attorney-Adviser, at (202) 551-3778 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Teri O'Brien