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Online Go to or scan the QR code - login details are located in the shaded bar below. Votes submitted electronically must be received by 11:59 p.m., Eastern Time on June 20, 2022. Stockholder Meeting Notice Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to be Held on June 21, 2022 The proxy materials for Spectrum Pharmaceuticals, Inc.'s annual meeting are available on the Internet or by mail. Follow the instructions below to view the materials and vote online or request a copy. The items to be voted on and location of the annual meeting are on the reverse side. Your vote is important! This communication presents only an overview of the more complete proxy materials that are available to you on the Internet or by mail. We encourage you to access and review all of the important information contained in the proxy materials before voting. The 2022 Proxy Statement and Annual Report are available online at: Easy Online Access - View your proxy materials and vote. Step 1: Go to Step 2: Click on Cast Your Vote or Request Materials. Step 3: Follow the instructions on the screen to log in. Step 4: Make your selections as instructed on each screen for your delivery preferences. Step 5: Vote your shares. When you go online, you can also help the environment by consenting to receive electronic delivery of future materials. Obtaining a Copy of the Proxy Materials - If you want to receive a paper or email copy of these documents, you must request one. There is no charge to you for requesting a copy. Please make your request for a copy as instructed on the reverse side on or before June 6, 2022 to facilitate timely delivery. 2NOT +


Stockholder Meeting Notice Spectrum Pharmaceuticals, Inc.'s Annual Meeting of Stockholders will be held on Tuesday, June 21, 2022 at Spectrum Pharmaceuticals, Inc.'s Research and Development East Office, 2 Atlantic Avenue, 6th Floor, Boston, Massachusetts 02110, at 10:00 a.m. Eastern Time for holders as of April 25, 2022. If you need directions to the Annual Meeting of Stockholders so that you may attend or vote in person, please contact our Chief Legal Officer, Keith M. McGahan, at (702) 835-6300. We may announce alternative arrangements for the Annual Meeting, which may include switching to a hybrid in-person/virtual format, a virtual-only meeting format or changing the time, date or location of the Annual Meeting. If we take this step, we will announce any changes through a press release that will also be filed with the SEC as additional proxy materials and we will post details at Please check in advance of the date of the Annual Meeting if you are planning to attend in person. As always, we encourage you to vote your shares prior to the Annual Meeting. Proposals to be voted on at the meeting are listed below along with the Board of Directors' recommendations. 1. Election of Directors. To elect (1) William L. Ashton; (2) Brittany K. Bradrick; (3) Seth H.Z. Fischer; (4) Juhyun Lim; (5) Thomas J. Riga and (6) Jeffrey L. Vacirca. 2. Advisory Vote on the Compensation of our Named Executive Officers. To approve, on a non-binding advisory basis, the compensation of our named executive officers, as disclosed in the Compensation Discussion and Analysis section of the Proxy Statement. 3. Amended and Restated 2018 Long-Term Incentive Plan. To approve the adoption of a proposed amended and restated Spectrum Pharmaceuticals, Inc. 2018 Long-Term Incentive Plan. 4. Ratification of Selection of Independent Registered Public Accounting Firm. To ratify the selection of RSM US LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2022. The Board of Directors recommends a vote FOR all nominees and FOR Proposals 2, 3 and 4. PLEASE NOTE - YOU CANNOT VOTE BY RETURNING THIS NOTICE. To vote your shares you must go online or request a paper copy of the proxy materials to receive a proxy card. If you wish to attend and vote at the meeting, please bring this notice with you. Here's how to order a copy of the proxy materials and select delivery preferences: Current and future delivery requests can be submitted using the options below. If you request an email copy, you will receive an email with a link to the current meeting materials. PLEASE NOTE: You must use the number in the shaded bar on the reverse side when requesting a copy of the proxy materials. - Internet - Go to Click Cast Your Vote or Request Materials. - Phone - Call us free of charge at 1-866-641-4276. - Email - Send an email to with "Proxy Materials Spectrum Pharmaceuticals, Inc." in the subject line. Include your full name and address, plus the number located in the shaded bar on the reverse side, and state that you want a paper copy of the meeting materials. To facilitate timely delivery, all requests for a paper copy of proxy materials must be received by June 6, 2022.